The monumental façade features three large round arches made of rusticated ashlar stone and resting on rectangular pillars that form a portico with plastered cross vaults. The rectangular building extends over three floors plus an attic with string courses and a denticulated cornice under the roof that accentuate its horizontality.
The entrance portal, also featuring a rounded arch in rusticated ashlar, is flanked by two segmental-arched windows with stone frames. On the first floor, three rectangular windows are topped by gables of various shapes (lobed and triangular), while on the upper floor are three simple stone-framed openings. On the south side, there is a 20th-century structure with a terraced roof supported by pillars and an arched opening. The interior façade, facing the courtyard, features rectangular windows with molded frames.
Since ancient times, the area has been called Borgo San Francesco, a name given to the church and convent that once stood along the street, now at number 36. Opposite Palazzo Beltrame, you can see the houses built against the city walls after the 1511 earthquake.
The Beltrame family played a significant role in the history of San Daniele del Friuli. A member of the family, Tebaldo Beltrame, was declared Count of the Holy Roman Empire and of the Austrian States in 1697.